Shapes & Symmetry
The more complex a shape is, the more difficult it is to extrude. Wherever you can, try to design simple shapes that are symmetrical with only gradual changes in the thickness of their sides.
You should also think about whether your design needs to be solid or hollow as this can also affect the ease of the extrusion process and the cost of the initial tooling. In certain situations, hollow shapes are easier to produce than solid ones.
You might also find that it’s more cost-effective to create two or more sections that can be assembled after the extrusion, instead of creating a single, complex extrusion.
Rounded corners are easier to extrude as the compound 'flows' through rounded corners much more readily. Where possible, radius all internal and external corners.